Rat urotensin-II-induced main pulmonary artery contractions are mediated by MAPK     

CHEN Shao-xian  XUE Bi-cheng  GONG Yong-sheng  FAN Xiao-fang  HU Liang-gang  CHEN Yan-fan  WANG Liang-xing 《园艺学报》2003,19(10):1365-1368

AIM: To investigate rat Urotensin-II(rat U-II)-induced vasoconstriction of rat main pulmonary arteries and the role of mitogen-activated protein kinase(MAPK). METHODS: The main pulmonary artery was dissected from the male Sprague-Dawley rats and artery ring width was 3-4 mm. Concentration-response curves were generated to rat U-II(0.03 nmol/L-30 nmol/L).Inhibitor of MAPK, PD 98059(0.1 μmol/L-10 μmol/L) were added into the medium after rat U-II(30 nmol/L)induced vasoconstriction had reached plateau to construct the relaxant concentration-response curves and their EC₅₀ and E_max. RESULTS：Rat U-II was a potent vasoconstrictor of isolated rat main pulmonary arteries [EC₅₀=7.95±0.40, E_max=(14.28±6.34)% of the response to 60 mmol/L KCl]; PD 98059 caused concentration-dependent relaxations of rat U-II precontracted arteries [EC₅₀=5.91±0.45, E_max=(81.39±13.65)%]. CONCLUSION: Rat U-II was a potent vasoconstrictor of rat main pulmonary arteries and this response was mediated through MAPK.  相似文献   

库布齐沙漠穿沙公路沙害综合防治技术   总被引：20，自引：4，他引：20  

胡春元  杨茂  杨存良  刘永茂  蒋有则  张润焕 《干旱区资源与环境》2002,16(3):71-77

库布齐穿沙公路修建在库布齐沙漠高大的流动沙丘区 ,风沙流侵袭与沙丘整体前移埋压公路是主要沙害形式。现有防沙措施是沙障保护下的人工植被及天然植被相结合的综合防护体系 ,固沙及阻沙效益明显。目前要解决的是尽快形成公路两侧稳定的植被群落 ,以保证公路的长期畅通  相似文献   

组氨醇脱氢酶抑制剂的研究动态     

胡利明  李学恕  刘钊杰 《农药学学报》2002,4(3):1-5

组氨醇脱氢酶(HDH)是组氨酸生物合成过程中最后两步反应的催化酶。对组氨醇脱氢酶的结构、催化机理、组氨醇脱氢酶抑制剂等方面的研究动态进行了较为详细的综述。  相似文献   

1-(1-苯基-1,2,4-三氮唑-3-氧代乙酰氧基)烃基膦酸酯的合成与植物生长调节活性   总被引：1，自引：0，他引：1  

贺红武  孟利平  胡利明  刘钊杰 《农药学学报》2002,4(3):14-18

合成了一系列新的1-(1-苯基-1, 2, 4-三氮唑-3-氧代乙酰氧基) 烃基膦酸酯, 并测定了它们对小麦和黄瓜的植物生长调节活性。结果表明, 在100 Lg/g 时, 所有化合物对小麦芽鞘的生长具有抑制作用, 而在10 Lg/g时化合物6a、6g 对黄瓜显示了较高的促生长活性。  相似文献   

新型取代氨基(或芳氧)磺酰基苯氧丙酸酯的合成及其除草活性   总被引：3，自引：0，他引：3  

胡方中  吕凯  任雪玲  陈彬 《农药学学报》2002,4(4):17-22

由α-苯氧基丙酸酯出发,合成了取代氨基(或芳氧)磺酰基苯氧丙酸酯,并测定了它们的除草活性。所有的化合物均经1H NMR和元素分析确证,初步的生测结果表明上述化合物具有一定的除草活性。  相似文献   

镧素对镰刀菌Fusarium solani及其致病酶的影响   总被引：2，自引：0，他引：2  

慕康国  张文吉  胡林  张福锁 《农药学学报》2002,4(4):56-60

采用琼脂平板生长速率法及液体培养基培养测定了La对镰刀菌Fusarium solani的抑制作用和毒力,并测定了其对病菌胞外的果胶酶、蛋白酶和纤维素酶等几种致病酶活性的影响。结果表明,随着La2O3浓度升高,对病菌菌丝生长的抑制作用增强,对病菌的EC50和EC95分别为278.2和552.0 mg/L;在一定浓度范围内,La提高了单位量菌丝所产生3种致病酶的活性,但由于菌丝生长受到抑制,除蛋白酶外,病菌胞外致病酶果胶酶和纤维素酶的总量或总活性受到了抑制,降低了病菌的致病力。  相似文献   

转Bt基因棉在安庆市大面积种植后害虫发生特点调查   总被引：6，自引：1，他引：6  

章炳旺  李恺求  朱世华  胡爱林  罗定荣  王俊 《中国植保导刊》2002,22(12):10-12

根据调查,转Bt基因棉大面积种植后,棉铃虫、红铃虫发生减轻;棉叶螨发生加重,为害时间延长;甜菜夜蛾、斜纹夜蛾发生面积扩大,为害程度加重。据此初步提出了当地转Bt基因棉害虫防治中应注意的问题和管理对策。  相似文献   

氮磷钾混合肥对锥栗坚果产量和质量的影响   总被引：4，自引：0，他引：4  

徐凤兰  王上伟  胡哲森  陆生泉 《落叶果树》2002,34(3):1-4

以 5年生锥栗为试树 ,进行土壤穴施氮磷钾混合肥试验 ,研究不同氮磷钾肥配比对锥栗坚果产量和质量的影响。结果表明 ,不同组合处理之间 ,除叶片的蛋白质含量和单株果枝数有显著差异外 ,叶绿素含量、单枝结棚数、单株结棚数、栗棚重、坚果重、出实率、单株棚产量和坚果产量的差异均不大。以穴施 0 .2 0kg尿素、0 .1 0kg钙镁磷和 0 .1 5kg氯化钾的混合肥较经济而有效  相似文献   

猴头菌优良菌株筛选研究初报   总被引：3，自引：0，他引：3  

胡建伟  龚明福  贾岩峰 《食用菌学报》2002,9(4):44-46

通过对六个猴头菌菌株菌丝生长情况，子实体农艺性状和产量的比较试验发现，HN、RT和猴杰2号综合性状较优，适合新疆阿拉尔地区代料栽培。  相似文献   

Effect of heat shock precondition on reperfusion arrhythmia in rats     

XIE Zi-an  HUANG Yuan-wei  HU Shen-jiang  XIA Qiang  SHEN Yue-liang 《园艺学报》2002,18(5):449-453

AIM:To investigate the effect of the heat shock response on the reperfusion arrhythmias(RAs) and the possible mechanism involved. METHODS:Fifty-five Sprague Dawley rats were randomly divided into 2 groups: the heat shock group (group H,n=29) and the control group (group C,n=26). The rats in group H were preconditioned with heat shock 24 hours before, and that in group C were not. The hearts of 16 rats in group H and 16 in group C were exercised and mounted on a non-circulating Langendorff perfusion apparatus and perfused retrogradely with modified K-H buffer and mimic ischemia/reperfusion was applied. Additionally, conventional intracellular microelectrode techniques were used for recording such electrophysiological parameters as resting potential(RP), action potential amplitude(APA), over shot(OS), maximum depolarization velocity(Vmax) of the hearts of other 13 rats in group H and 10 in group C. RESULTS:①Prior heat stress significantly decreased reperfusion arrhythmia. ②The amount of CK release in the effluent in group H was much less than that in group C. ③Myocardial HSP70 content was elevated significantly in group H. ④Heat stress significantly increased myocardial anti-oxydases activity and decreased lipid peroxydative products. Additionally, heat stress significantly reduced the Vmax of action potential. It indicated that rapid Na⁺ channel of papillary muscles may be inhibited by heat shock. The degree of change of Vmax after ischemia in H group was significantly less than that in group C. And the time of reperfusoin with Tyrode's solution till the action potential appeared as large as that before perfusion with mimic ischemic solution is shorter in group H than in group C. CONCLUSION:Heat shock pretreatment markedly reduces ischemia/reperfusion-induced injury of heart and ventricular arrhythmias in rats and this effect may be associated with the inhibition of rapid Na⁺ channel of papillary muscles by heat shock and the increase in myocardial HSP70 and anti-oxydase activity.  相似文献